Tag Archives: Medicine

FDA approved PEGylated drug

To date, eleven PEGylated proteins, antibody fragments, oligonucleotides, and small molecules have been approved by FDA are on the market, including PEGylated bovine adenosine deaminase: pegademase bovine (Adagen); and PEGylated l-asparaginase: pegaspargase (Oncaspar); PEGylated products of interferon-alpha (IFN-alpha): peginterferon-2b (PegIntron) … Continue reading

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FDA Approves Constipation Drug PEGylated Naloxol

FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in … Continue reading

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High-density lipoprotein mimetic drug delivery systems for cancer, cardiovascular diseases

Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved … Continue reading

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Skin Penetrating Peptides Enhance Transdermal Delivery of Hyaluronic Acid

As a major component of the skin extracellular matrix, Hyaluronic Acid (HA) is involved in various biologic processes such as hydration, nutrient exchange, and cell differentiation and motility. Frequently, due to its high molecular weight and charge, HA is a … Continue reading

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PEGylation Protocols and Literature References

Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These paper describe detailed procedures … Continue reading

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PEGylated Hyaluronic Acid Nanoparticle Drug Delivery

A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. “The most effective antitumor … Continue reading

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Surfactant-like PEG derivatives for drug delivery

Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase at http://www.creativepegworks.com. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, … Continue reading

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