Category Archives: PEG Derivatives

FDA Approves Constipation Drug PEGylated Naloxol

FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in … Continue reading

Posted in PEG Derivatives, PEGylated Products on Market, PEGylation Success Stories | Tagged , , , , | 2 Comments

High-density lipoprotein mimetic drug delivery systems for cancer, cardiovascular diseases

Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved … Continue reading

Posted in PEG Derivatives, PEGylation Reagents | Tagged , , , , , , | Leave a comment

PEGylation Protocols and Literature References

Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These paper describe detailed procedures … Continue reading

Posted in PEG Derivatives, PEGylation Reagents, PEGylation Tools | Tagged , , , | Leave a comment

PEGylated Hyaluronic Acid Nanoparticle Drug Delivery

A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. “The most effective antitumor … Continue reading

Posted in PEG Derivatives, PEGylation Reagents, PEGylation Success Stories | Tagged , , , | Leave a comment

Surfactant-like PEG derivatives for drug delivery

Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase at http://www.creativepegworks.com. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, … Continue reading

Posted in PEG Derivatives, PEGylation Reagents, PEGylation Tools | Tagged , , , , | Leave a comment

Fluorescent or Radioactive PEG-like Nanoprobes

Researchers from the Massachusetts General Hospital and Harvard Medical School developed novel “PEG-like Nanoprobes’’ with controllable pharmacokinetics and  tunable fluorescence. The “PEG-like Nanoprobes’’ nanoparticles feature a unique design where a single PEG polymer surrounds a short fluorochrome and radiometal bearing … Continue reading

Posted in PEG Derivatives, PEGylation Reagents, PEGylation Success Stories, PEGylation Tools | Leave a comment

Designer Proteins Trigger Cell Death – a new cancer therapy?

Researchers from University of Washington and the Howard Hughes Medical Institute use an innovative computational design approach coupled with in-vitro-targeted evolution to produce a potent polypeptide inhibitor that triggers apoptosis of virus-infected cancer cells, suppresses tumor growth and extends survival … Continue reading

Posted in PEG Derivatives, PEGylation Reagents, PEGylation Success Stories | Tagged , , , | 1 Comment