Monthly Archives: August 2015

Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs

Hydrogels have gained significant attention as ideal delivery vehicles for protein drugs. However, the use of hydrogels for protein delivery has been restricted because their porous structures inevitably cause a premature leakage of encapsulated proteins. A simple yet effective approach … Continue reading

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The stealth properties of PEG-coated nanoparticles are dependent on the PEG grafting densities

Originally posted on Creative PEGWorks:
The Lai lab at UNC Chapel Hill published an article in Molecular Pharmaceiuticals – Evading Immune Cell Uptake and Clearance Requires PEG Grafting at Densities Substantially Exceeding the Minimum for Brush Conformation. Mol. Pharmaceutics, 2014,…

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